My research is currently funded by NIH grants.
My research covers several broad areas in statistics genetics and genomics: methods for mapping genes for complex diseases, methods for integrative analysis of genomic data and methods for microbiome and metagenomics. From 1998 to 2012, I was supported by an NIH R01 grant (ES009911) to develoop methods for mapping genes for complex diseases, including methods for linkage, association, haplotype and admixture mapping. My method research on genomic data analysis was supported by a NIH R01 grant, focusing on developing statistical and computational methods for analysis of genomic data with graphical structure, and another R01 grant focusing on analysis of next generation sequencing data. I was also the PI of a T-32 traininng grant "Training in Ophthalmic Statistical Genetics and Bioinformatics" to train investigators in the area of statistical genetics for ophthalmic genetics.
My current research focuses on statistical and computational issues related to analysis of microbiome and metagenomics data.
I also collaborate with other people on genetic studies of complex diseases and biological systems. I worked with Dr. Glenys Thomson at UC Berkeley on the Biostatistics Core for the 13th International Histocompatibity Working Group and was the PI of Biostatistics and Bioinformatics Core for the Project "A Mitochondrial Longevity Pathway: P66Shc Mechanisms" during 2007-2008. Funded by several NIH R01 grants, I am also collaborating with Dr. Maris, Dr. Struan and Dr. Hakonnarson at the Children's Hospital of Philadelphia on genome-wide association studies of neuroblastoma, childhood obesity and childhood asthma. Finally, I am collaborating on several projects on analysis of human gut and lung microbiome studies (collaborators: Ron Collman, Rick Bushman, Gary Wu and Jim Lewis).
I was/am PI of the following NIH grants:
NIH R01-ES009911, 1998-2001: Survival Models for Mapping Genes for Complex Diseases.
NIH R01-ES009911, 2002-2006: Survival Models for Mapping Genes for Complex Diseases.
NIH R01-ES009911, 2007-2012: Survival Analysis Methods in Genetic Studies.
NIH R01-CA127334, 2007-2012: Methods for Genomic Data with Graphical Structures.
NIH R01-CA127334, 2012-2017: Methods for Genomic Data with Graphical Structures.
NIH T32-EY021451, 2011-2016: Training in Ophthalmic Statistical Genetics and Bioinformatics.
NIH R01-GM097505, 2012-2016: Statistical Methods for Next-Generation Sequence Data.